The program of the 3rd International Definiens Symposium, June 14-16, in Munich is approaching its final shape and we are very happy about the line-up of very interesting speakers.

Register now to secure your early bird discount (until April 15).

The 3rd International Definiens Symposium 2012 in Munich will take place at Definiens’ headquarters in the Arnulfpark, Munich and the close-by Ernst & Young Auditorium. Join us to learn more about recent developments in Quantitative Digital Pathology and cutting-edge biomedical image and data analysis. You will hear about groundbreaking research and exchange experiences with other Definiens users. In addition to our dynamic plenary sessions and fruitful networking breaks, this year we will be adding extensive hands-on workshops to our lineup.

Click here to see recordings of last year’s meeting at the Moffitt Cancer Center, FL.

Read More…

Quantitative Digital Pathology Out-of-the-Box: Definiens Tissue Studio Combines Flexibility and Ease-of Use with High Productivity

Get an introduction to the straigthforward configuration of image analysis solutions with Definiens Tissue Studio. With no more than a few clicks, you can assemble a solution that is adjusted to the specific properties of your tissue sample and that provides you with the quantitative readouts you require. Per region of interest. Per cell. Per cell compartment. Definiens Tissue Studio readily analyzes images from any solid tissue, stained with IHC, H&E or IF. Register now.

Date: Thursday, March 29
Time: 4 pm CEST / 10am EDT / 7am PST
Speaker: Daniela Längin, Definiens

Amy Abernethy from the Age of Personalized Medicine wrote an insightful note on the importance of understanding the complexities of cancer for progress in personalized medicine. She comments on an article in the March 8 issue of The New England Journal of Medicine, and concludes that

“the authors of “Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing” provide an exquisite roadmap of how heterogeneous and complex one individual’s cancer can be with many mutations lurking within each tumor mass, and the mutations themselves evolving over time.”

She discusses some of the challenges for personalized treatment resulting from this heterogeneity and the value of biopsies:

“While a single needle biopsy may not create a complete picture of a cancer, biopsies are still a crucial part of characterizing tumors, using growing scientific knowledge to understand which treatments might work best. Biopsies are a starting point. A number of institutions are conducting genetic and genomic analyses on tumors. This is probably not the Holy Grail, but rather an iterative step in a long trail of scientific advances that will support personalization of cancer medicine. In addition, new technologies are needed to improve on the information gathered, including methods to understand whole tumor heterogeneity.”

I agree. Genomic analyses are certainly very valuable and multiregion sequencing will help revealing intratumor heterogeneity. I also agree that genomic analyses are probably not the Holy Grail. I believe that the new technologies needed to improve on the information gathered may well include sophisticated image analysis. Tumor heterogeneity is well apparent in tissue morphology and can be studied to reveal contributions of morphologically distinct cell populations (attend a free upcoming webinar held by Mark Lloyd, Moffitt Cancer Center, for a stunning example). Image analysis can also be used to enhance the accuracy of multiregion sequencing – if regions to be sequenced are selected based on tissue morphology.
Read More…

Definiens enjoyed lively disucussions with attendees of USCAP 2012. We’re happy about the strong interest in our image and data analysis solutions for quantitative digital pathology. Thank you!

Read More…

Read More…

Read More…

Read More…

Read More…

Our partner OracleBio, a UK-based image analysis service provider with Definiens Tissue Studio capabilities, met Her Royal Highness (HRH) Princess Anne as part of a royal visit to Scotland in February of this year. The Princess Royal’s visit formed part of the naming of a new state of the art bio-incubator facility called ‘Biocity Scotland’ with OracleBio being one of the first tenants. During the visit, Princess Anne was introduced to Definiens software by Dr Lorcan Sherry and was given a live demonstration of Tissue Studio’s capabilities.

Munich, Germany, March 19, 2012 — Definiens®, the leading provider of image analysis and data mining solutions for quantitative digital pathology, today announced it will expand its already comprehensive product portfolio with additional stereological analysis methods. Stereology can be incorporated into both manual and automated whole slide image analysis workflows. Find more under http://info.definiens.com/stereology.html.
Read More…

Are you thinking about how to unlock the full potential of digital slides most effectively? Correlate unbiased and quantitative readouts provided by automated image analysis with patient outcome or therapy response. Retrieve comprehensive morphological fingerprints and molecular expression profiles on a cell-by-cell basis from digital slides.
Definiens solutions for Quantitative Digital Pathology support your goals in R&D, pre-clinical safety, clinical studies, translational medicine and the development of tissue diagnostics. Visit us at booth #807 to learn more on the novel functionality available with Definiens Tissue Studio 3.5 and the recently introduced Definiens Image Miner.

The following talks by some of our customers will provide an excellent overview of benefits from using Definiens solutions for image and data analysis:

[2139] Novel Quantitative Image-Analysis Based Scoring Technique for In-Situ Assessment of mRNA in Archival Tumor Tissues: Strong Correlation between Manual and Automated Schemes    Authors: Jeffery C Hanson, Timothy R Holzer, Angie D Fulford, Robert J Konrad, Aejaz Nasir   Date/Time: Monday, March 19, 2012 - 1:00 PM   Session Info: Poster Session II # 308, Monday Afternoon   Location: CC Exhibit Hall B3 & C

[1389] Automated Image Analysis and Scoring of Tartrate Resistance Acid Phosphatase Preparations  Authors: Bryan Dangott, Mohamed Salama   Date/Time: Wednesday, March 21, 2012 - 9:30 AM   Session Info: Poster Session V # 212, Wednesday Morning   Location: CC Exhibit Hall B3 & C

[1634] Validation of Automated Image Analysis for Hematopathology    Authors: Bryan Dangott, Nisha Ramesh, Tolga Tasdizen, Mohamed Salama   Date/Time: Tuesday, March 20, 2012 - 1:00 PM   Session Info: Poster Session IV # 221, Tuesday Afternoon   Location: CC Exhibit Hall B3 & C

[1487] Notch/HES1 and PARP1 Protein Co-Expression among B-Lymphoblastic Leukemia/Lymphoma Patients (pts) Predicts Good Prognosis    Authors: Adnan Mansoor, Payam Pournazari, Michelle Dean, Sarah-Joy Haggstrom, Brant Pohorelic, Farid Kosari, Meer-Taher Shabani-Rad, Jay Patel, Iwona Auer, Xiu Yan Jiang, Doug Demetrick, Nizar Bahlis, Douglas Stewart, Alexander C Kilmowicz   Date/Time: Monday, March 19, 2012 - 2:00 PM   Session Info: Platform Session: Section C, Monday Afternoon   Location: CC 211-214

We hope to meet you in Vancouver!

The Definiens Team

Read More…

Read More…

Read More…

Read More…

Read More…

Read More…

Video recordings from some of the presentations held at the Second International Definiens Symposium at the Moffitt Cancer Center in Tampa, Florida, are now available on YouTube. The following list provides an overview of currently available recordings and the video below gives you a short impression of the event.

THOMAS HEYDLER – Welcome address to the Second International Definiens Symposium

ROBERT GILLIES – Multiscalar Image Analysis: A Window onto Tumor Heterogeneity

JARED SCHWARTZ – Digital Pathology and Image Analysis: The Window to Personalized Medicine

ALEXANDER HEIDRICH – Automated Feature Extraction from microPET/CT Images of Live Chick Embryos in ovo: Incubating a Versatile Model for Preclinical Imaging

VIKAS PRASAD – Translation of Histopathological Information to in vivo Molecular Imaging using PET/CT and therapeutic Management

CLEOPATRA KOZLOWSKI – An Entirely Automatic Method to Score Crypt Loss and Infiltration from Pathology Slides in a Mouse DSS Model of Colitis

JOSEPH KRUEGER – Digital Pathology and IVDMIAs: the Shortest Distance Between Two Points

GLYN COLEBROOKE – Digital Histopathology, Stratified Medicine and Robust Companion Diagnostics

GÜNTER SCHMIDT – Power of Numbers: Cell-by-Cell Analysis with Tissue Studio 3.0

JOHANNES ZIMMERMANN – Extending the Limits: Definiens Developer XD 2

ARNO SCHÄPE – Extracting the Essence: Definiens Image Miner 1.0

Read More…