From the editor: Definiens recently launched a new version of the leading image analysis solution for quantitative digital pathology, Tissue Studio. I will briefly introduce its main features in a loose sequence of posts trying to answer one of the following questions each.

What can Tissue Studio do for you?
Who is Tissue Studio designed for?
Why is Tissue Studio the solution of choice?

Please watch out for forthcoming entries to learn more on new functionality of the new version or have a look at the recordings of the introductory webinar.

What can Tissue Studio do for you? Here’s an example: You have a large set of image data; say tissue micro array (TMA) cores from patients with esophagogastric cancer stained for HER2. After very limited configuration, Tissue Studio automatically:

• identifies regions of interest on each core
• detects nuclei and membrane within each region of interest
• separates individual cells
• measures staining intensity of the membrane and membrane closure per cell
• computes a HER2/neu score per individual cell
• counts the number of cells with a HER2 score of 0, 1+, 2+ and 3+, respectively
• uses these counts to determine the HER2 score for each core
• provides comprehensive readouts including quantitative data on all of the above

Similar readouts can be generated to answer your specific question. Definiens Tissue Studio readily analyzes  image data from any solid tissue and supports IHC, H&E and IF.